Applied Research on Preparation Technology of Nano-Plant Powder Milling

The development of nano-plant powder products has been relatively slow, particularly when it comes to natural plant-based health foods such as nano-pollen, fungi, and other valuable medicinal plants like ginseng, ganoderma spores, pearls, and cordyceps. Additionally, the production of nano-plant powders from toxic medicinal plants, such as sphagnum, is still in its early stages. This field presents both scientific and technical challenges. From a scientific perspective, there have already been published studies on the application of nano-plant powders. However, this article focuses more on the technical challenges involved in their production. Two innovative technologies developed by Lu Qing and Qu Yuan—multi-dimensional oscillating nano-ball milling and multi-level grading nano-ball milling—have significantly advanced the field. The former has already received patents, while the latter is currently undergoing trials. The first technology, multi-dimensional oscillating high-energy nano-ball milling, uses rapid, multi-directional movement within the tank to create intense impact forces. This increases the energy and trajectory of the grinding media, reducing blind spots and improving efficiency by up to ten times compared to traditional ball mills. As a result, particles can be reduced to the nanometer scale with excellent uniformity, achieving a particle size of around 10 nm. This closed system has been successfully applied by Qinhuangdao Taiji Ring Nano-product Co., Ltd. to produce nano-foods like nano-tea and nano-coffee, as well as nano-medicines such as external pastes. The second technology, multi-level grading nano-ball milling, mimics the motion of a bartender’s arm, allowing for two-way, repeated operations that enhance the probability of grinding media collision. This leads to high-energy impacts and a graded crushing effect, resulting in particles as fine as 10 nm. This open system allows for continuous feeding and discharging, and can be used for dry or wet grinding. It is suitable for a wide range of materials, including plants, metals, minerals, ceramics, and non-flammable organic and inorganic substances. Despite these advancements, several challenges remain in the preparation of nano-plant powders: 1. **Temperature Control**: High-energy ball milling generates significant heat, which can cause thermal degradation of plant materials. To address this, water-cooled jackets are used to maintain stable temperatures during processing. 2. **Moisture Management**: Plant materials often contain high levels of moisture, increasing their toughness. Drying at 55°C for 4–6 hours helps reduce moisture and improve brittleness before ball milling. 3. **Sticky and Viscous Materials**: Some plants, especially those high in sugar or oils, tend to stick to the grinding media. Wet slurry grinding followed by spray drying is an effective solution to prevent clumping and ensure better dispersion. 4. **Pollution Concerns**: Steel balls used in traditional ball milling can contaminate the product. Replacing them with zirconia balls and using zirconia-lined tanks reduces contamination, making the process safer and more efficient. 5. **Particle Agglomeration**: Due to their high surface energy, nano-particles tend to clump together. Adding food-grade dispersants or modifying the surface during ball milling improves stability and solubility. 6. **Particle Size and Uniformity**: While smaller particles may seem ideal, they can increase instability and side effects. A particle size between 60–180 nm is considered optimal, ensuring good absorption without compromising stability. Looking ahead, nano-plant powder technology holds great promise. Plants contain essential nutrients and medicinal compounds that are more effectively absorbed when broken down into nano-scale particles. With ongoing improvements in ball milling techniques, this technology is becoming a viable and cost-effective method for producing high-quality, bioavailable plant-based products. Japan has already taken the lead in applying ultra-fine technology to traditional Chinese medicine, but our team was among the first to introduce high-energy nano-ball milling into the plant and herbal medicine industry. This innovation is set to revolutionize the food, health, cosmetic, and pharmaceutical sectors, offering products with enhanced solubility, absorption, and efficacy. As we continue to refine these methods, nano-plant powders will play a key role in advancing natural health solutions worldwide.

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L-serine, as a basic amino acid of protein, is widely used in medicine, food, cosmetics and other industries. At present, the global market demand for L-serine is 10000t / A. L-serine is a non essential amino acid, which is an important precursor involved in the synthesis of intracellular biological substances such as purine, pyrimidine and phospholipid. L-serine is a raw material for compound amino acid infusion, and can also be used as a raw material for light chemical industry . In addition, L-serine is widely used in advanced cosmetics at home and abroad because of its special wettability and moisture retention

D-serine is one of the most important D-type amino acids in mammals, which is about 1 / 3 of the total free serine. It has been found that high concentration of D-serine exists in the higher center of higher animals, including human beings, and it plays an important role in neurotransmitter. It is found that D-serine plays an important role in the corpus cavernosum and lower esophageal sphincter of mice.

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Xi'an Tian Guangyuan Biotech Co., Ltd. , https://www.tgybiotech.com