According to Xinhua News Agency, Tokyo, February 19 (Reporter: Lan Jianzhong), a research group of Yokohama City University in Japan announced that they have cultivated islet-like tissue with a three-dimensional structure by culturing pancreatic β cells in a simulated microgravity environment.
The researchers said that if the pancreatic beta cells are cultured in petri dishes, they can only form flat tissues and their ability to make insulin is low. They rotate the container containing the culture fluid to give the container a microgravity environment inside. The pancreatic β cells of the mice were cultured under the environment and as a result, almost the same tissues as the islets of the mice were cultured. The researchers also succeeded in culturing rat pancreatic beta cells in the same way.
The researchers say that this three-dimensional tissue is very similar to pancreatic islets made up of beta cells, but it is more capable of producing insulin. Researchers transplanted this tissue into diabetic model mice and their blood glucose levels dropped significantly.
The researchers said that if the pancreatic beta cells are cultured in petri dishes, they can only form flat tissues and their ability to make insulin is low. They rotate the container containing the culture fluid to give the container a microgravity environment inside. The pancreatic β cells of the mice were cultured under the environment and as a result, almost the same tissues as the islets of the mice were cultured. The researchers also succeeded in culturing rat pancreatic beta cells in the same way.
The researchers say that this three-dimensional tissue is very similar to pancreatic islets made up of beta cells, but it is more capable of producing insulin. Researchers transplanted this tissue into diabetic model mice and their blood glucose levels dropped significantly.
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