Newly discovered bacteria will adhere to host cells like "glue"

   Xinhua News Agency, Washington, March 31 (Reporter Zhou Zhou) An international study found that bacterial pathogens have evolved an efficient survival strategy that will adhere to the host like a nylon "gluing" on clothes. On the cell. The new findings will help people better cope with bacterial infections.
Researchers at the University of Munich in Germany and the University of Illinois in the United States said in a new issue of the journal Science that Staphylococcus epidermidis adheres permanently to host cells. To analyze this adhesion mechanism, they used a "two-pronged approach". Methods: On the one hand, the binding force between the adhesion protein of Staphylococcus epidermidis and its ligand was studied by atomic force microscopy. On the other hand, detailed molecular dynamics simulation was carried out by means of supercomputer. It was found that the strong binding between the bacterial adhesion protein and its ligand was "surprising."
The study found that the bacterial adhesion protein and its ligand form a dense non-covalent hydrogen bond network, the structure is very stable, the principle is similar to the "gluing", one side is a lot of small hooks, the other side is a lot of small rings, very It is difficult to pull it apart.
The researchers say the new findings reveal the physical principles of adherence of host cells to host cells, which are essential to prevent bacterial infections and help develop new antibacterial therapies.

Monobenzone

Monobenzone can decompose melanin in the skin, and prevent the formation of melanin in the skin, used for the treatment of hyperpigmentation, such as various spots, age spots, melanoma. In addition as intermediates in organic synthesis.

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1.Monobenzone is a compound used as a topical drug for medical depigmentation.

2.The topical application of monobenzone powder in animals decreases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.

3.Monobenzone may cause destruction of melanocytes and permanent depigmentation.

4.The histology of the skin after depigmentation with topical monobenzone powder is the same as that seen in vitiligo.

5.The epidermis is normal except for the absence of identifiable melanocytes.


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