Guangzhou Biological Institute and other new progress in AIDS vaccine research
November 01, 2018 Source: Chinese Academy of Sciences
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, and other units have made new progress in the research of AIDS preventive vaccines. The relevant results are published in the International Immunology Journal Frontiers under the title of Immune protection of SIV challenge by PD-1 blockade during vaccination in rhesus monkeys. In Immunology.
Tumor immunotherapy strategies based on PD-1 signaling pathway blockade are in full swing, but their application in the field of infectious disease prevention and control has not been carried out in depth. The human immunodeficiency virus (HIV) has been discovered for more than 30 years and is still the fourth leading cause of human death. Although drug therapy can control AIDS, it cannot be cured, and patients need to take medicine for life. For the control and elimination of the AIDS epidemic, the development of effective preventive vaccines is widely considered to be the most cost-effective strategy.
HIV/SIV-specific CD8+ T cells play a key role in the clearance and control of HIV/SIV infection, and if they can fully induce persistent high levels of virus-specific CD8+ T cells, they will help control and eliminate HIV/SIV against target cells. Infection. Using the macaque/SIV infection model, the researchers explored an immunization strategy based on the combination of an adenoviral vector-based AIDS vaccine and PD-1 antibody. The results indicate that the simultaneous use of PD-1 antibody during vaccination can effectively reduce the functional depletion of T cells and induce a more effective, broad-spectrum and long-lasting killing CD8+ T cell immune response, and can also effectively prevent monkey HIV. Multiple high dose infections of SIVmac239. The study provides a new strategy for developing effective preventive AIDS vaccines.
Pan Enxiang and Feng Fengling, graduate students of the Guangzhou Institute of Biological Sciences, are the co-first authors of the paper. Chen Linghe and Sun Caijun, who have joined Sun Yat-sen University, are the co-authors of the paper. The research was funded by the National Major Science and Technology Special Project, the Guangdong Science and Technology Plan, and the Guangzhou Special Innovation Project.
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