1. Antitussive effect: The decoction of Pinellia ternata, Pinellia ternata, Pinellia ternata and Pinellia ternata, 0.6-1g/kgig or iv, has obvious effect on the cough caused by cat iodine solution injected into the chest cavity or electrical stimulation of the laryngeal nerve The antitussive effect can be maintained for more than 5 hours. The antitussive effect of 0.6 g/kg was similar to that of codeine 1 mg/kg.
2. Inhibition of glandular secretion: Pinellia preparation ip has a significant inhibitory effect on salivary secretion caused by pilocarpine. It is also reported that saliva secretion increases first and then decreases after decoction po.
3. Antiemetic and vomiting effects: Various preparations of Pinellia oleifera, heat-treated or added with alum and ginger, have certain antiemetic effects on vomiting caused by desorption of morphine, digitalis, and copper sulphate. The above three emetics have different mechanisms of action, and Pinellia can show antiemetic effects, presumably its antiemetic mechanism is the inhibition of vomiting center.
4. Anti-fertility effects: The anti-fertility rate of the first trimester mice was 0.25 mg/ml (0.9% NaCl) sc0.2 ml. After the crystalline Pinellia protein is denatured by 6M guanidine hydrochloride, stepwise dialysis (ie, diluting the denaturant with equal volume of the buffer) is used to restore the balance of Pinellia protein in physiological saline. After removing the denaturant, the protein can be renaturalized. Restore its original vitality. The recovery rate of Pinellia protein from different reversal conditions was 69-88% in mice against early pregnancy. Only one reversal condition was 5-8°C, and the rate of inhibition of pregnancy was only 36%.
The use of horseradish peroxidase-labeled localization showed specific binding of endometrial cells, ductal epithelial cells, and certain parts of the cytoskeleton of the embryonic exteromal disc and the Pinellia protein. These sites are likely to be part of the anti-progestational role of exogenous protein half protein. Direct injection of Pinellia protein into the uterine cavity of mice also indicates anti-pregnancy effects. If the above binding site is indeed Pinellia protein affecting the implantation of the endometrium and embryos in mice, resulting in anti-pregnancy effects, these sites may also play a role in the identification of the bed, because Pinellia protein can not only terminate the mouse's early pregnancy There is also the effect of stopping the implantation of rabbit blastocysts. Pinellia protein also has a strong anti-rabbit blastocyst implantation, intrauterine injection of 500ug, anti-implantation rate of 100%. The endometrium after the action of Pinellia protein can not implant the normal blastocyst. The blastocysts incubated in the uterus with Pinellia protein were transplanted into a synchronous pseudopregnant uterus, and the implantation rate decreased as the incubation time prolonged.
5. Inhibition of trypsin: Pinellia trypsin inhibitor only inhibits the hydrolysis of amides, esters, hemoglobin, and casein by trypsin and does not inhibit chymotrypsin, bradykinin, papain, papain, and papain. Hydrolysis of the respective substrate. The inhibitory ratios of inhibitors to porcine trypsin hydrolysis of amide, ester, hemoglobin, and casein were 1:0.71, 1:0.88, 1:0.71, and 1:0.71, respectively. From the chemical molecular size range, Pinellia trypsin inhibitor should be a macromolecular inhibitor. 6. The pharmacological effects of processed products: Qing Banxia (according to the Chinese Pharmacopoeia 85 year edition method) decoction 200% concentration 26.5ml/kg prophylactic administration, there is obvious ventricular arrhythmia induced by strontium chloride Counteraction (P
6. The role of anti-cancer: Pharmacological experiments showed that the dilute alcohol or aqueous leachate of Pinellia palmata had significant inhibitory effects on experimental tumors and Hela cells. The fenugreekine base obtained from the water-soluble fraction also has a significant inhibitory effect on mouse liver cancer (HCA). The β-sitosterol and analogues contained therein also have anti-tumor effects. And can obviously promote the gradual shedding of cancer cells and make the cancer shrink or disappear. Clinical pharmacological observations are effective for cervical cancer and have a clear local cleaning effect.
7. Other effects:
7.1. Promotion of cell division: The mitogenic effect of Pinellia protein is also specific to animal species. It promotes the transformation of peripheral blood lymphocytes in rabbits but does not promote the division of human peripheral blood lymphocytes.
7.2. Coagulation: Pinellia protein is also a lectin, which has a unique hemagglutination activity with rabbit erythrocytes. The degree of aggregation is still as low as 2 μg per 1 ml. In addition to red blood cells, there are also agglutination of red blood cells in sheep, dogs, cats, guinea pigs, rats, mice and pigeons. However, the red blood cells of humans, monkeys, pigs and chickens, ducks, geese, turtles, crickets, and cockroaches do not agglutinate. Pinellia protein is the only known lectin-binding protein that binds only to mannose but not to glucose. In addition to erythrocytes, Pinellia protein also agglutinates other cells, and mouse spleen cells, human hepatoma cells (QGY7703-3 and 7402), Ehrlich ascites carcinoma, and ascites liver cancer cells can all be agglutinated by Pinellia protein, but it does not agglutinate large. Mouse epididymis and porcine omentum adipocytes, although it can bind to both cells. It is suggested that the cell agglutination of Pinellia protein not only has animal species specificity but also has cell type specificity.
7.3. Antihypertensive effect: Pinellia extract has inhibitory effects on isolated wow hearts and rabbit hearts. Iv has a transient hypotensive effect on dogs, cats, and rabbits and is rapidly tolerated. Decoction ig mice have mild stimulatory effects on adrenocortical function. If administered continuously, it can cause functional inhibition.
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