The business club reported on January 31 that simvastatin caused rhabdomyolysis and blindness in Avastin patients. Warnings for adverse drug reactions occurred frequently in 2010. Therefore, in the 2011 work report of the Qingdao Food and Drug Administration, it is necessary to increase monitoring of adverse drug reactions. How do they detect and monitor adverse reactions? What will happen after discovery? There was an adverse reaction monitoring center in the Affiliated Hospital. On January 25, when interviewing Meng Debao, deputy chief physician of the Department of Pharmacy at the Affiliated Hospital of QingYi, he said: “There are many missing reports. The more patients reported, the more favorable it is for patients. ."
Two cases of anaphylactic shock were returned
In April last year, Meng Debao received a phone call from a pediatrician in the hospital: A 7-year-old girl suddenly developed anaphylactic shock after she had been given promethazine and scopolamine injections. “These two drugs were used for pre-operative sedation and had never had any problems before.†Meng Debao immediately went to the pediatric department after receiving the call. “The used injections, lot numbers, and all the equipment doctors are all left. Record these After that, he quickly came back and checked the records of the drugs.†The children had already been rescued and everyone was relieved. But what are the causes of anaphylactic shock? Is this drug? There was no answer at this time until one case of anaphylactic shock occurred one day later. Meng Debao immediately asked for the storage of the type and batch of drugs, and contacted the manufacturers to send them back immediately.
The life-saving drug turned into a "skin pill"
Symptoms of clinical adverse reactions include nausea, vomiting, and pruritus, which are particularly mild symptoms. However, in the Department of Dermatology of the Affiliated Hospital of Qingyi Medical University, Meng Debao once discovered several cases of serious adverse reactions from the outside. The whole body's skin fell down, and some places were just bloody. The culprit causing these symptoms turned out to be the life-saving drug - Kama. Xiping. "Carbamazepine is a medicine that is specialized in the treatment of epilepsy. Its cheap price is good for symptom control, but the adverse reactions it causes are scary." Meng Debao said that the patient he saw was 52 years old. Three months of carbamazepine, a sudden appearance of molting.
616 cases reported in 2010
The Provincial Affiliated Hospital Adverse Reaction Monitoring Center has been established for 8 years. At present, the hospital also has basic medicines, but there is no separate monitoring. Meng Debao said: “We monitor all medicines, no matter which kind of medicines.†According to statistics, the 2010 green The Medical Affiliated Hospital reported a total of 616 cases of adverse reactions. Of these, antibiotics account for nearly half, and some oncology chemotherapy drugs are also included. What does the 616 figure mean? More or less? Meng Debao frankly said: "It is not much because there are a large number of missed reports. We can only use these three methods to obtain the maximum scope of monitoring, but there is still a part that cannot be monitored at all."
The more reported, the more beneficial in the future
In the interview, Meng Debao repeatedly emphasized: “I hope that after the adverse reactions, the public can actively report to the public. We urgently need such a situation. The more adverse reactions reported, the more supervision of the drug is added and the manual is improved. Symptoms of adverse reactions.†For example, after a drug called Bezostine was launched in 1997, it was found through adverse reactions that it could cause rhabdomyolysis and renal insufficiency. In 2001, the instructions were revised and the drug was withdrawn from the market.
Therefore, Meng Debao also reminded that do not think that the adverse reactions on the brochure are not important, so be sure to read it before taking medicine. In addition, once you discover any unpleasant symptoms, you should report it to the pharmacy or hospital where you bought the medicine. The more you report, the more beneficial you will be to the patient.
Two cases of anaphylactic shock were returned
In April last year, Meng Debao received a phone call from a pediatrician in the hospital: A 7-year-old girl suddenly developed anaphylactic shock after she had been given promethazine and scopolamine injections. “These two drugs were used for pre-operative sedation and had never had any problems before.†Meng Debao immediately went to the pediatric department after receiving the call. “The used injections, lot numbers, and all the equipment doctors are all left. Record these After that, he quickly came back and checked the records of the drugs.†The children had already been rescued and everyone was relieved. But what are the causes of anaphylactic shock? Is this drug? There was no answer at this time until one case of anaphylactic shock occurred one day later. Meng Debao immediately asked for the storage of the type and batch of drugs, and contacted the manufacturers to send them back immediately.
The life-saving drug turned into a "skin pill"
Symptoms of clinical adverse reactions include nausea, vomiting, and pruritus, which are particularly mild symptoms. However, in the Department of Dermatology of the Affiliated Hospital of Qingyi Medical University, Meng Debao once discovered several cases of serious adverse reactions from the outside. The whole body's skin fell down, and some places were just bloody. The culprit causing these symptoms turned out to be the life-saving drug - Kama. Xiping. "Carbamazepine is a medicine that is specialized in the treatment of epilepsy. Its cheap price is good for symptom control, but the adverse reactions it causes are scary." Meng Debao said that the patient he saw was 52 years old. Three months of carbamazepine, a sudden appearance of molting.
616 cases reported in 2010
The Provincial Affiliated Hospital Adverse Reaction Monitoring Center has been established for 8 years. At present, the hospital also has basic medicines, but there is no separate monitoring. Meng Debao said: “We monitor all medicines, no matter which kind of medicines.†According to statistics, the 2010 green The Medical Affiliated Hospital reported a total of 616 cases of adverse reactions. Of these, antibiotics account for nearly half, and some oncology chemotherapy drugs are also included. What does the 616 figure mean? More or less? Meng Debao frankly said: "It is not much because there are a large number of missed reports. We can only use these three methods to obtain the maximum scope of monitoring, but there is still a part that cannot be monitored at all."
The more reported, the more beneficial in the future
In the interview, Meng Debao repeatedly emphasized: “I hope that after the adverse reactions, the public can actively report to the public. We urgently need such a situation. The more adverse reactions reported, the more supervision of the drug is added and the manual is improved. Symptoms of adverse reactions.†For example, after a drug called Bezostine was launched in 1997, it was found through adverse reactions that it could cause rhabdomyolysis and renal insufficiency. In 2001, the instructions were revised and the drug was withdrawn from the market.
Therefore, Meng Debao also reminded that do not think that the adverse reactions on the brochure are not important, so be sure to read it before taking medicine. In addition, once you discover any unpleasant symptoms, you should report it to the pharmacy or hospital where you bought the medicine. The more you report, the more beneficial you will be to the patient.
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