Adult chicken maduramycin poisoning

Maduramycin is a new type of specific anti-coccidial drug. It has the characteristics of high efficiency and low price, so it is well received by the chicken farmers. However, due to the small dose of this drug, blindly increasing the dose in some specialized chicken farmers, poisoning often occurs. Now a case of adult chicken maduramycin poisoning is introduced as follows:

Incidence

2600 laying hens were raised by Wang, a 7th township of Wei County, Hebei Province. The chickens were housed regularly and immunized according to normal immunization procedures. The survival rate was 98% at 103 days of age. The chickens grew well and they were found at 106 days of age. There is red loose stool in the feces of the chickens. Without veterinary diagnosis, they believe that they are coccidiosis, and they drink water with maduramycin. According to instructions, maduramycin should add 10 liters of water per milliliter. To control the epidemic as soon as possible, add 1 liter of water per milliliter to allow the chickens to drink freely. After drinking for 2 hours, chickens will have about 50% of chicken gizzards. Soft, non-food, and non-drinking, 5 were dead at the time, more than 100 died in the evening, and 180 died the next day. On September 6, 2007, the sick and dead chickens were brought to the Xingtai City Veterinary Hospital for treatment.

Clinical symptoms

The diseased chickens are depressed, have no appetite and desire for drinking, squat wings, some crouching, knees on both knees, and some have neurological symptoms, twist their necks, turn around or star-like, feces are yellowish green and loose stools.

Necropsy changes

A total of 15 sick and dead chickens were necropsied and had good nutrition. The chest and leg muscles were slightly congested and bleeding. The hernia sac was filled with food, the liver was swollen, and there were bleeding points. The gallbladder was swollen with bile; the spleen was swollen. Coronary fat bleeding, severe myocardial hemorrhage. The intestinal mucosa showed diffuse hemorrhage, bleeding between the glandular and stomach nipples, and slight bleeding of the glandular and stomach nipples. Among them, there were few swollen chicken bursa with little swelling, but no bleeding and exudates.

Laboratory diagnosis

Aseptically, the blood, liver and spleen tissues of sick chickens were smeared and Gram stained and Wright's stained and microscopic examinations were performed. No bacteria were found.

The liver was taken as nutrient agar for bacterial culture and no bacterial growth was observed.

In the Newcastle disease HI test, the average geometric value of the antibody was 9.41og2, and there was no unevenness in the antibody level.

Comprehensive diagnosis

According to the incidence, clinical symptoms, necropsy changes, laboratory diagnosis, a comprehensive diagnosis of maduramycin poisoning.

treatment

Immediately stop drinking water containing maduramycin, drink 5% glucose water in groups, add vitamin C2 (500 mg/kg) per kilogram of water, and use a mixed-use tree bar in the feed (as specified) to adopt the above method. As a result, deaths quickly decreased, with a total of 455 deaths in three days, with a mortality rate of 17.5%.

summary

This time chicken maduramycin poisoning is mainly caused by blindly increasing the dose of chicken farmers, mistakenly believe that maduramycin has no toxic side effects, the greater the dose, the faster coccidiosis control. Therefore, the concentration was increased by 10 times and poisoning occurred, causing large numbers of chickens to die. Therefore, when advising chicken specialists in using any medicines, they must follow the instructions when they do not understand the toxic side effects of the drugs. Do not blindly increase the dose to avoid poisoning and cause unnecessary economic losses.

In the use of anticoccidial drugs, we must master the dose, such as the occurrence of acute morbidity after the use of drugs, high mortality, it should first consider drug poisoning, must be immediately discontinued, timely diagnosis and treatment.

When an outbreak occurs in a flock, an experienced veterinarian should promptly find out the cause of the disease and apply the medicine to the patient in order to control the loss to a minimum.

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