Small-Molecule Inhibitor API Ponatinib (CAS: 943319-70-8)

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Model NO.: Pharmaceutical Grade
Product Name: Ponatinib
Model No.: Atc-166
Molecular Formula: C29h27f3n6o
Molecular Weight: 532.22
Product Specifications: Pharmaceutical Grade
MOQ(Minimum Order Quantity): 10g
Origion: Hubei, China
Brand: Biocar
Market: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bag or as Required
Specification: SGS/ CTI/ ITS
Origin: Hubei, China
HS Code: 8676530000
Model NO.: Pharmaceutical Grade
Product Name: Ponatinib
Model No.: Atc-166
Molecular Formula: C29h27f3n6o
Molecular Weight: 532.22
Product Specifications: Pharmaceutical Grade
MOQ(Minimum Order Quantity): 10g
Origion: Hubei, China
Brand: Biocar
Market: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bag or as Required
Specification: SGS/ CTI/ ITS
Origin: Hubei, China
HS Code: 8676530000
High Purity Small-molecule Inhibitor API  Ponatinib(CAS:943319-70-8)
 
Chemical Information
 
Quick Details:
Product Name Ponatinib
Molecular Formula C29H27F3N6O
Molecular Weight 532.22 
Storage 3years in -20ºC 
Targets Abl PDGFRα VEGFR2 FGFR1  c-Src 
IC50 0.37 nM 
IC50 1.1 nM 
Dosage Oral administration, 1-25 mg/kg, once daily for 4 weeks 
 
Product Name: Ponatinib
Other Name:AP24534(Ponatinib);3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;AP24534;Ponatinib;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib (AP24534);Ponatinib (with 4 ints.);3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
Model No.: ATC-166
CAS No.: 943319-70-8
Molecular Formula: C29H27F3N6O
Molecular Weight:532.22
Stability: N/A
Target:N/A 
Appearance: White or Nearly White Crystalline Powder
Melting Point: N/A
Purity: 99%+
Suitable People: ALl
Product Specifications: Pharmaceutical Grade 
Standard: Qualified
MOQ(Minimum Order Quantity): 10g
Payment: L/C, T/T, Western Union
Shipment: EMS, DHL, FedEx, TNT
Packing: Aluminium Foil Bag or as Required    
Brand: Biocar
Origion: Hubei,China  
Export Markets: Global   
         
Product Description
Ponatinib (trade name Iclusig, previously AP24534) is an oral drug developed by ARIAD Pharmaceuticals for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors.
 
Oncologists have complained, however, that many patients cannot afford the "astronomical" cost of $138,000 a year, which makes it one of the most expensive drugs in medicine, and far more expensive than what is needed to pay the development costs.
 
The United States Food and Drug Administration approved the drug as a candidate in 2012, but temporarily suspended sales on 31 October 2013 because of "the risk of life-threatening blood clots and severe narrowing of blood vessels".[5][6] This suspension was partially lifted on Dec. 20, 2013 with ponatinib being issued revised prescribing information, a new "Black Box Warning" and a "Risk Evaluation and Mitigation Strategy" in place to better evaluate the risks and benefits of using the drug.
 
Applications/Usage
1.AP24534 is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.
 
2.Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.
 
3.Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively
 
Target
Abl     PDGFRα   VEGFR2    FGFR1          Src
  
Dosage
Oral administration, 1-25 mg/kg, once daily for 4 weeks
 
====================================================
 
Our Advantages
1.High quality and competetive price
1)For exported we can offer COA Certificate and official Invoice.
2)We are manufacturer with own lab and factory, can provide high quality products with factory price. 
3)Products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.
 
2.Fast and safe delivery:
1)Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7X24h for you to contact.
2) Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
3)Customs pass and satisfied rate ?Y99%.
4)For hot sale products we have stock in there for transferring. 
 
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

 
Other Small molecular API:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
 
Delivery Time
About 7 days
 
 
====================================================
 
Contact Us
Tel: 86-027-86879876
Mobile: 86-15327198583
Fax: 86-27-87050469
Website: http://www.besteroid.com/
Online Store:http://biocar.en.made-in-china.com/
©Wuhan Biocar Bio-Pharm Co., Ltd.



Delivery:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
 

Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%. 


====================================================
Contactct:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.


Newbio is a reliable supplier and looks for a long term business relationship!!!

High Purity Small-molecule Inhibitor API  Ponatinib(CAS:943319-70-8)
 
Chemical Information
 
Quick Details:
Product Name Ponatinib
Molecular Formula C29H27F3N6O
Molecular Weight 532.22 
Storage 3years in -20ºC 
Targets Abl PDGFRα VEGFR2 FGFR1  c-Src 
IC50 0.37 nM 
IC50 1.1 nM 
Dosage Oral administration, 1-25 mg/kg, once daily for 4 weeks 
 
Product Name: Ponatinib
Other Name:AP24534(Ponatinib);3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;AP24534;Ponatinib;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib (AP24534);Ponatinib (with 4 ints.);3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
Model No.: ATC-166
CAS No.: 943319-70-8
Molecular Formula: C29H27F3N6O
Molecular Weight:532.22
Stability: N/A
Target:N/A 
Appearance: White or Nearly White Crystalline Powder
Melting Point: N/A
Purity: 99%+
Suitable People: ALl
Product Specifications: Pharmaceutical Grade 
Standard: Qualified
MOQ(Minimum Order Quantity): 10g
Payment: L/C, T/T, Western Union
Shipment: EMS, DHL, FedEx, TNT
Packing: Aluminium Foil Bag or as Required    
Brand: Biocar
Origion: Hubei,China  
Export Markets: Global   
         
Product Description
Ponatinib (trade name Iclusig, previously AP24534) is an oral drug developed by ARIAD Pharmaceuticals for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors.
 
Oncologists have complained, however, that many patients cannot afford the "astronomical" cost of $138,000 a year, which makes it one of the most expensive drugs in medicine, and far more expensive than what is needed to pay the development costs.
 
The United States Food and Drug Administration approved the drug as a candidate in 2012, but temporarily suspended sales on 31 October 2013 because of "the risk of life-threatening blood clots and severe narrowing of blood vessels".[5][6] This suspension was partially lifted on Dec. 20, 2013 with ponatinib being issued revised prescribing information, a new "Black Box Warning" and a "Risk Evaluation and Mitigation Strategy" in place to better evaluate the risks and benefits of using the drug.
 
Applications/Usage
1.AP24534 is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.
 
2.Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.
 
3.Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively
 
Target
Abl     PDGFRα   VEGFR2    FGFR1          Src
  
Dosage
Oral administration, 1-25 mg/kg, once daily for 4 weeks
 
====================================================
 
Our Advantages
1.High quality and competetive price
1)For exported we can offer COA Certificate and official Invoice.
2)We are manufacturer with own lab and factory, can provide high quality products with factory price. 
3)Products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.
 
2.Fast and safe delivery:
1)Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7X24h for you to contact.
2) Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
3)Customs pass and satisfied rate ?Y99%.
4)For hot sale products we have stock in there for transferring. 
 
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

 
Other Small molecular API:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
 
Delivery Time
About 7 days
 
 
====================================================
 
Contact Us
Tel: 86-027-86879876
Mobile: 86-15327198583
Fax: 86-27-87050469
Website: http://www.besteroid.com/
Online Store:http://biocar.en.made-in-china.com/
©Wuhan Biocar Bio-Pharm Co., Ltd.



Delivery:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
 

Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%. 


====================================================
Contactct:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.


Newbio is a reliable supplier and looks for a long term business relationship!!!

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