A cancer research published online by Nature in the UK on the 12th said that scientists at the Massachusetts Institute of Technology in the United States have used CRISPR-Cas9 technology to find that supplementation with histidine will help enhance the efficacy of a common chemotherapy drug, thereby reducing toxic effects. Use of side effects drugs.
Methotrexate is a chemotherapy drug used to treat solid tumors and blood cancers. As an antimetabolite, methotrexate can prevent the synthesis and repair of cancer cell DNA and the synthesis of proteins required for cancer development. The main mechanism is to inhibit the synthesis of tetrahydrofolate (THF), and tetrahydrofolate is not compatible with nucleotide synthesis. Missing ingredients. The shortcoming of methotrexate is that it is too toxic and should not be taken in large doses. To this end, researchers are eager to find a way to enhance the effect of methotrexate on cancer cells.
This time, MIT scientist David Sabottini and his colleagues used the CRISPR-Cas9 gene editing technology to screen for methotrexate-treated leukemia cells to identify genes with increased sensitivity to methotrexate. .
In this way, the researchers discovered a process associated with methotrexate sensitivity, an enzymatic process that facilitates the breakdown of histidine, and histidine is used to synthesize amino acids in proteins. Like methotrexate, the catabolism of histidine also reduces the level of tetrahydrofolate in cells, but not by inhibiting the synthesis of tetrahydrofolate, but by consuming tetrahydrofolate, thereby enhancing the presence of methotrexate on tumor cells. Inhibition.
Mouse experiments have shown that taking a small dose of methotrexate while taking histidine during chemotherapy is particularly effective in reducing tumors and killing tumor cells. The research team said that if these results are transformed into clinical trials, the simple and economical dietary intervention can improve the effects of methotrexate-based chemotherapy, so doctors can also reduce the toxic side effects of patients. Methotrexate. (Reporter Zhang Mengran)
Editor-in-chief
Chemotherapy drugs are currently one of the main means of treating tumors. But their killing is indiscriminate - killing tumor cells and killing normal tissue cells. Therefore, clinically used chemotherapeutic drugs have varying degrees of toxic side effects - this is also the most direct cause of limiting drug dosage. If a technical means can improve the efficacy of chemotherapy drugs, it will reduce the amount of drugs, while greatly improving the safety index.
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CRL-40,941 is a molecule similar to adrafinil, and has been shown to be more effective than these two molecules in their indications, with fewer side effects.
Significant positive effects of CRL-40, 941 include improved memory, greater mental clarity, increased ambition, and overall higher levels of mental performance. As it improves focus, it could be used to treat conditions such as ADHD, Alzheimer's and depression. It also has great use in the treatment of sleep disorders, such as insomnia or narcolepsy.
Application Functions:
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2. Increased learning ability
3. Improve cognitive processing
4. Improve your responsiveness
5. Improve your perception
6. Reduce anxiety
Reduce depression
What is the application of CRL-40 941?
* Applied in the pharmaceutical field.
* Used in the field of cosmetics.
Describe :
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