Eat a big fat man - OB / OB leptin-deficient mice
The current economic development has made the lives of the people around us better and better. However, with the improvement of living standards, some "rich diseases" caused by obesity have become more and more prominent. As a good disease model animal for studying obesity and type 2 diabetes, OB/OB leptin-deficient mice play an indispensable role in the research of these diseases. Today, we will bring you B-OB/ Partial experimental data from OB mice.
1. Introduction to OB/OB mice
Leptin is a peptide hormone composed of a peptide chain. It is mainly secreted by fat cells, and its expression is mainly in white adipose tissue. In addition, it is expressed in myocardium, skeletal muscle, placenta, lung, mammary epithelium and gastric mucosa. It can functionally suppress appetite, increase energy consumption, and inhibit fat. Synthesis promotes its decomposition. Insulin can promote the secretion of leptin, which in turn plays a negative feedback regulation on the synthesis and secretion of insulin.
Ob is a coding gene for leptin, and B-ob/ob mice prepared by knocking out ex genes 2 and 3 exons using EGE technology have obesity and hyperglycemia symptoms, and are researching hyperglycemia and obesity. A powerful model .
2, basic information
3. Gene editing strategy
4. Model verification and analysis
1, B-ob/ob mouse weight detection
The results showed that the body weight of the homozygous B-ob/ob mice was continuously higher than that of the control group at 4 weeks of age.
2, B-ob/ob mouse blood glucose test
The results showed that the blood glucose of the homozygous B-ob/ob mice (-/-) was continuously higher than that of the control group at 4 weeks of age.
Ok!
OB/OB mice are introduced here for everyone.
We have live female mice, and we want to buy them quickly .
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The company is currently located in Yizhuang, Beijing. It has branches in Shanghai Zhangjiang, Jiangsu Haimen and Boston, USA, and has offices in Wuhan, Guangzhou and Chengdu. Where.
Established in the United States in 2008 and successfully operated. In 2009, Beijing Baiao Saitu Headquarters was established, and in 2012, the headquarters was relocated to Beijing Yizhuang Economic and Technological Development Zone.
Bio-Saitu is a high-tech company based on a stable and efficient gene editing technology platform, with model animal customized services, important model animal development and large-scale breeding and supply, in vivo pharmacological efficacy evaluation services, and antibody drug research and development outsourcing services. Biopharmaceutical companies.
The company adheres to the principle of pursuing better human health and aims to provide high quality products and services for new drug research and development.
Innovative models to empower health sciences
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Beijing
Beijing Baiao Saitu Gene Biotechnology Co., Ltd.
Address: 12th Floor, Building 3, No. 88, Kechuang 6th Street, Yizhuang Economic and Technological Development Zone , Beijing
Hotline: 010-56315318
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Jiangsu
Baiao Saitu Jiangsu Gene Biotechnology Co., Ltd.
Address: Building B10, Biomedical Science and Technology Pioneer Park, Linjiang New District, Haimen City, Jiangsu Province
Hotline: 0513-68015890
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Beijing Baiao Saitu Gene Biotechnology Co., Ltd. Shanghai Branch
Address: Room 811, 812, No. 780, Cailun Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai
Hotline: 021-50703895
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Biocytogen Boston Corp.
Address: 50D Audubon Road, Wakefield, Massachusetts, USA 01880
Phone: 781-587-3555
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